 | Related Articles |
Natively unfolded state for engineering nanoscale fibrillar arrays.
Macromol Biosci. 2012 Feb;12(2):195-201
Authors: Ryadnov MG, Cherny DI
Abstract
A generic rationale for the fabrication of high aspect ratio fibrillar nanoscale arrays is described. The design emulates an intermittence effect observed for ?-structured ?-synunclein fibrils, reported herein, in a structurally unrelated ?-helical fiber. The generated nanoarrays are composed of periodic nanosized segments separated at uniform distances of unfolded regions. These regions can be targeted for conformational binding and refolding with metal nanoparticle-peptide conjugates for the conversion of fibrillar arrays into nanoparticle arrays. The introduced concept opens new strategies for engineering novel nanoscale materials and devices.
PMID: 22147495 [PubMed - indexed for MEDLINE]
Natural products custom peptide price kinase inhibitor library for screening
No comments:
Post a Comment