Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases.

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Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases.

J Periodontal Res. 2012 Jul 19;

Authors: Jeong E, Lee JY, Kim SJ, Choi J

Abstract
Jeong E, Lee J-Y, Kim S-J, Choi J. Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases. J Periodont Res 2012; doi: 10.1111/j.1600-0765.2012.01501.x.�2012 John Wiley & Sons A/S Background and Objective:? Autoimmune diseases, including atherosclerosis, diabetes mellitus and rheumatoid arthritis, can be triggered and aggravated by the pathogen-driven antigenic peptide from Porphyromonas gingivalis HSP60. P. gingivalis is the major pathogen of chronic periodontitis, which is a global epidemic prevalent in two-thirds of the adult population. The monoclonal antibody raised against peptide 19 (Pep19: TLVVNRLRGSLKICAVKAPG) from P.�gingivalis HSP60 was polyreactive to the human homolog. The aim of this study was to determine if Pep19 from P.�gingivalis HSP60 manifests itself as a predominant antigen in infection-triggered autoimmune diseases. Material and Methods:? Pep19 from P.�gingivalis HSP60, Mycobacterium tuberculosis HSP60 and Chlamydia pneumoniae HSP60 was synthesized for comparative recognition by the sera from patients with atherosclerosis, type 2 diabetes and rheumatoid arthritis, all with ongoing periodontal disease, and by the sera of a control group of patients with periodontal disease but with no history of atherosclerosis, type 2 diabetes or rheumatoid arthritis. Results:? Of the Pep19 peptides from P.�gingivalis HSP60, M.�tuberculosis HSP60 and C.�pneumoniae HSP60, Pep19 from P.�gingivalis HSP60 was the peptide epitope predominantly and most consistently recognized by the serum samples of the four disease groups (chronic periodontitis, atherosclerosis, type 2 diabetes mellitus and rheumatoid arthritis). Conclusion:? Seroreactivity to Pep19 of P.�gingivalis HSP60, an oral pathogen, was predominant in patients with autoimmune disease with ongoing periodontal disease.

PMID: 22812430 [PubMed - as supplied by publisher]

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